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Sentinel vs. Trifexis: Which All-in-One Preventive is Best for Your Pet?
Posted by PetMeds Pro on October 14, 2011
Filed under PetMeds Spotlight

Get Sentinel at 1-800-PetMeds.comGet Trifexis at 1-800-PetMeds.com

If you’re like most pet owners, you want to provide your pet with the best protection from parasites with the least risk, hassle (for you and your pet), and cost. To help you decide which all-in-one preventive is best for you, we’ve put together a comparison of two major all-in-ones: Sentinel and Trifexis.

Similarities between Sentinel and Trifexis

Both Sentinel and Trifexis:

  • Contain the active ingredient Milbemycin Oxime, so they both treat and control roundworms, hookworms, and whipworms and protect against heartworms
  • Are chewable tablets that should be given once a month
  • Require a prescription from your veterinarian
  • Can be purchased online at 1-800-PetMeds

Differences between Sentinel and Trifexis

  • Cost
    One dose of Sentinel costs about $5 less than one dose of Trifexis.
  • Age at which each can be administered
    Sentinel can be given to puppies at beginning at 4 weeks; Trifexis can be given to puppies beginning at 8 weeks.
  • Minimum weight requirements
    Sentinel can be given to dogs as small as 2 pounds; Trifexis can be given to dogs as small as 5 pounds.
  • Flea control properties
    Sentinel contains Lufenuron, which prevents flea egg development and ends the flea life cycle, but doesn’t kill adult fleas; Trifexis contains Spinosad, which kills fleas (it has been proven to kill 100% of all biting fleas within four hours).
  • Cautions
    You should be cautious when giving any medication to your pet. And make sure you mention any other prescription medications or supplements you’ve given your pet to your veterinarian so he or she can check for drug interactions. Both have the potential for drug interactions. Trifexis carries the following caution: “Serious adverse reactions have been reported following concomitant extra-label use of ivermectin with spinosad alone, one of the components of Trifexis chewable tablets.”
  • Side effects
    With Sentinel, side effects are rare, but they can occur and may include vomiting; Trifexis may cause vomiting, and other side effects are less likely but possible.
  • Customer reviews
    Sentinel has a 4.6-star rating average from 341 of our online shoppers, and Trifexis has a 3.8-star rating average from 68 customers.

We hope that this comparison has helped you decide which all-in-one preventive is right for you. Once you’ve decided, we hope you’ll visit 1-800-PetMeds for all of your pet supplies. Happy shopping!

Update 11/13/2013:  According to the FDA and Eli Lilly, Trifexis is safe and effective when used according to label instructions.  Unfortunately a small percentage of dogs may experience adverse reactions when taking this or any medication.  We encourage pet owners to consult their veterinarian before administering Trifexis or any other medication to their pets.

No related posts.

84 Responses to “Sentinel vs. Trifexis: Which All-in-One Preventive is Best for Your Pet?”

  1. Angela Burkard on 15 May 2012 at 9:55 pm #

    Interesting comparison between Sentinel and Trifexis. . . . .Our mutt (SPCA Special – Black Golden Retriever / Australian Shepherd mix) used to take Sentinel with no problems. Trifexis is another thing – she gets really lethargic and sleepy. . . . Also, it’s very difficult to give Lina the Trifexis pill (she tends to spit them out). Lina is about 62 pounds and is on the 61 lbs – 100 lbs dose. . . . Too much? Not sure, the Vet seems to think it’s okay.

    Anyone else having a very sleepy dog after giving Trifexis?

  2. Vicki Mitchell on 29 May 2012 at 3:40 pm #

    My little Pom had trouble taking the smallest dose, which made her quite lethargic, even vomited one month. The next month I split the pill in 2, gave her half with breakfast, half with dinner, smashed up the pill in her food. Worked much better. She used Sentinel for years with no problem then six months ago she suddenly had fleas and tapeworms, thus the switch.

  3. cheryl on 30 May 2012 at 1:53 pm #

    ask your vet about MDR1 gene Mutation: breeds affected by these gene are: Hearding Breeds such as the australian shepherd, border collie, ect. Trifexis has Ivermectin, which these breeds should not have. Dogs that carry this gene, and use of these drugs can cause serious neurological illness or death.

  4. storm on 31 May 2012 at 9:59 am #

    @cheryl, what preventative do you use on a MDR1 breed?

  5. Jennifer on 03 Jun 2012 at 2:07 pm #

    @cheryl- Trifexis does not contain ivermectin, nor does sentinel. Trifexis contains milbemycin and spinosad. Sentinel contains milbemycin and lufenuron.
    @storm- Trifexis and Sentinel are both safe to use in MDR1 breeds, of course provided there are no other health problems that may prevent them from taking either product.

  6. Jody on 07 Jun 2012 at 3:33 pm #

    Angela,
    Yes, I noticed both my dogs (Swedish Vallhunds-herding) were lethargic after taking Trifexis. I asked my vet about it and he said it was safe but did offer to order Sentinel for me if I wanted. I’ve kept an eye on them each month after giving it to them and have noticed lethargy, sometimes in one dog but not the other. My younger dog hates taking it (spits it out even if hidden in cheese) whereas the Sentinal she ate by itself like a treat. I’m going to ask to switch back to Sentinel this month. We’ve never had flea problems so don’t see the need to treat with additional flea killer that is in Trifexis if we don’t have any issues. I think my dog is trying to tell me something by spitting the pill out!

  7. Rebecca on 11 Jun 2012 at 10:52 am #

    I had our Lab/Wolfhound mix on Sentinel for 7 years and he died of blood cancer a few months before he turned 8. Research showed it was related to the Sentinel. I have recently put our new dog on Trifexis because she is allergic to topical flea treatment. I have seen no problems with it, no vomiting and no lethargy. She is as active as ever. I give it to her with peanut butter and put it on the roof of her mouth and she will swallow it that way.

  8. Deb on 19 Jun 2012 at 3:56 pm #

    What research associated Sentinel to blood cancer?

  9. Matt on 21 Jun 2012 at 4:33 pm #

    Milbemycin is listed as one that should not be givin to dogs with MDR1!

  10. Sean on 24 Jun 2012 at 7:35 pm #

    @ Cheryl – The Iverhart medications contain ivermectin.

  11. Reggie on 02 Jul 2012 at 9:14 pm #

    Since Sentinel is on national backorder for another several months (maybe longer), we’re all stuck w/Trifexis (that is, all of us who need to buy the pills now).

  12. Greg on 11 Jul 2012 at 1:23 am #

    From what I have heard, Sentinel will no longer be made. The only plant that made the product was shut down by inspectors and the rumor is they will not reopen the plant and will not make the product at any of their other facilities. Triflexis is the only alternative that is a one-dose form that I know of (everything else is a oral and topical combination).

  13. Catherine on 02 Aug 2012 at 8:54 pm #

    My border collie/labrador mix (62-65 lbs) has been on Trifexis 4 months. She refuses to take it so it ends up in her food dish. This month shedecided to act like a cat and refused to eat at all until bribed by parmasen alfredo sauce on the food which killed the taste. She’s been horribly lethargic since. This will be her last month on Trifexis.

  14. Dale on 15 Aug 2012 at 10:40 am #

    My friend went through living hell with this poison.

    One dog dead, another almost there.

    Both were fine before the trifexis treatments.

    Do the research, you will see. Google and read the painful reviews and comments.

    My friend learned the hard, and sad, way.

  15. collette kuemmel on 15 Aug 2012 at 12:27 pm #

    trifexis killed my chihuahua after 10 days of suffering, at the same my wheaten is getting weakerrags has had his spleen removed and he now has pancreatitis. i am thankful for every day i have him. trifexis is legalized poison fda approved

  16. PV on 06 Sep 2012 at 9:22 am #

    I am wondering if anyone have a recommendation for something besides sentinel & Trifexis? I live in FL and the vet tells me that this is the best thing for fleas because they are such a problem here. I don’t want my dogs to have fleas, but at the same time, I do not want to harm my dogs. I am very concerned. I do not know what to believe. When I was up north with my previous dog (years ago), the topical we used worked fine. Is anyone else in FL or a southern state & if so, are the fleas really that much more of a problem? I appreciate any suggestions…Thanks!

  17. Whitney on 06 Sep 2012 at 3:24 pm #

    I have two dogs (3 year old female Lab and 4 year old female doxie) and neither of them have had any problems with Trifexis. Neither of them like the taste, but we give their dosage with treats. They have yet to become lethargic, and have been on it for over 1 year. I was interested in something that was just as good, but a bit cheaper…which is a little hard to find. I love Trifexis and fully believe in it. I don’t believe that Trifexis alone has cause some of the problems listed above..there has to be something else involved, such as sudden change from one heart worm pill to Trifexis, or illness that was already occurring, and owner’s did not know, therefore, the side effects of Trifexis did not help, BUT does not mean Trifexis cause the problem. I do not know anything about Sentinel, but thought about changing from Trifexis, until now. I have no problem, except for the price, of Trifexis…but that can be over-looked for the health of my dogs. So Trifexis I will stick with.

  18. tra on 13 Sep 2012 at 11:25 am #

    PV ..if its just fleas try comfortis

  19. Hannah on 02 Oct 2012 at 9:56 pm #

    If you have a large dog, good luck finding the Comfortis for large dogs. That is what me and my Mom give to our dogs but everywhere we look it’s on back order. That’s why I’m now trying to find something else. I was actually thinking about trying the Sentinal since it kills the eggs but maybe not now.

  20. Amelia quattrociocchi on 03 Oct 2012 at 3:24 pm #

    I have a Jack Russel who is 12 years old and I must say very active.. When I take him out people think that by the way he acts that is is 3 years old. We have always given him Sentinel but since they are not making this anymore ( so I was told ) started him on Trifexis.. He started with this in June and since then he has been loosing a lot of his hair, and I don’t mean shedding!!!! Patches all over his body.. The vet took some skin from him and sent it way to see what this is… He was perfectly fine until he took this Trifexis… Can someone out there give me some feedback… PLeeease!!!!

  21. S on 04 Oct 2012 at 8:56 pm #

    All of these comments scare me too death. How can the FDA allow for Sentinal to quit being made; especially, with so awful an alternative? I just do not know. I gave my baby, puppy mill mix, one tablet tonight. However, I guess we will go for Heartguard and Comfortis, and if we can’t find Comfortis, it will be Frontline for fleas. Dang it.

  22. Don on 15 Oct 2012 at 4:26 pm #

    @Matt: MDR1 gene is associated with Ivermectin sensitivity, NOT Melbemycin.
    References:
    http://www.vetmed.wsu.edu/depts-VCPL/drugs.aspx
    http://www.laboklin.co.uk/laboklin/showGeneticTest.jsp?testID=8032

    However, I’m reading a lot of complaints on the Internet about symptoms potentially linked to Trifexis.

  23. Susan on 31 Oct 2012 at 10:54 pm #

    My Miniature Schnauzer has been on Trifexis for six months and seems to have no adverse reaction to it. I have not seen any change in his mood or activity level. So far, I am satisfied with the product.

  24. Erin on 06 Nov 2012 at 3:38 am #

    My shepard mix takes trifexis. He does throw up here and there for no reason, however he is NEVER lethargic. I went on vacation to a place that had a flea outbreak pretty much. He never brough one home with him. I strongly live trifexis. Like the old saying goes, ” you get what you pay for.”

  25. Nancy on 19 Nov 2012 at 7:01 pm #

    My yorkie-poo took Trifexis for the first time, the first of the month. He is 8 1/2 lbs and a very picky eater he swallowed the portion provided by the vet and had no problems after the treatment.

  26. Kristen on 20 Nov 2012 at 12:33 am #

    Our Lab has been on Trifexis since he was a pup. He’s a year and a half now. Never had a problem with him being lethargic or any GI issues. Animals are like people when it comes to medication. I’m severely allergic to penicillin but plenty of people take it with no problem. I’d say it makes perfect sense that some dogs can take Trifexis and be fine, while others have reactions to it. No need in calling it poison or being scared of it. If you try it and don’t like the effects or possible reaction, then you just need to find a good alternative. It can be annoying I’m sure, but obviously worth the expense and/or aggravation. We’ve been very happy with Trifexis. We live down south where fleas are a definite nuisance and have yet to see a one with the help of this medicine. We’re not only protecting our 95 pound baby from fleas and ticks, but from heartworms as well. The cost is by far worth it and pays for itself in the long run. I am sorry to all the babies out there who have had severe reactions to it. I hope all the owners find a worthy alternative!

  27. Cathy on 30 Dec 2012 at 9:45 pm #

    I moved to Arkansas 6 months ago, after living in the Southwest for many years and I have always had dogs. In the southwest I don’t think I ever saw a flea on any of my pets. Since Moving to Arkansas it seems they breed by the minutes. The house and yard we moved into was completely infested with them. We have sprayed the yards, bombed the house and continue to do so regularly. We tried some of the otc/store bought flea prevention treatments with some success, but it was very time consuming for 2 dogs. We rescued a corgi mix puppy after losing a long time mini pin to old age with heart problems, from the first day the puppy came home she was covered in fleas. When she was still you could actually see them everywhere on her even with a double coat they were everywhere. With three dogs now a 15 lb terrier/poodle, a 20 lb boston terrier and now a 30 lb corgi mix that was a lot of fleas, so I consulted our long time 2nd generation family vet and we decided the triflexis was the best choice. I did my homework and did the research before starting the treatment. Now I am so happy we started using triflexis. We never see any fleas on the dogs or in the house. I still use insect/parasite treatments on the yards/lawns where our dogs run and play. With 3 dogs on the triflexis for 6 months, they have all had a little vomiting once each and there was some sleepys in the beginning but nothing compared to the disease, worms and misery caused by the flea infestation. I agree with Kristen that it is unfortunate that some pets have had an adverse reaction to the triflexis but that it may be an individual thing or possibly related to undiagnosed disease already present in some. I don’t want to think of the alternative to not having the triflexis for my babies. If you price the cost of monthly heartworm treatments, the cost of routine worming along with the cost of flea/tick prevention and the price of triflexis is a bargain.

  28. Harriet on 01 Jan 2013 at 10:09 pm #

    I no longer can use Interceptor- unavailable- my 11 year old Collie has mutated gene so nothing with Ivermectin and that includes Heartguard and she vomited after Trifexis. Also, she is an unreliable eater so we can’t ensure dosing her on a full stomach.
    Vet suggested Revolution- topical application. She had her first application this evening. Does anyone have experience with this drug?

  29. Anne on 06 Jan 2013 at 2:10 am #

    Our large, mixed breed dog took 4 doses of Trifexis and will never take another dose. The first 2 doses caused mild lethargy for about a day, and I mentioned it to our vet. She advised us to give the next dose with a meal, which we did–no problems that month. Everything went downhill from there. 12 hours after taking the 4th dose, our dog was vomiting, lethargic, disoriented, and moaning. It was horrible! I called our vet, who was very defensive regarding any problems caused by Trifexis. After much research, it seems hundreds, even thousands, of dogs have had terrible side effects from this drug. Another interesting factor is that shortly after the 3rd dose, our active, 3 year old dog began limping on 3 of her legs. We spent over $1200 trying to diagnose the problem. I have read similar stories from people suspecting Trifexis has caused joint and inflammation problems. Don’t give this to your dog–it’s not worth the risk!!

  30. Fraancesca on 09 Jan 2013 at 11:15 pm #

    I have a small 5lb 1 1/2 yeaar old yorki poo.After her first dose of trifexis she vomited 4 times on day 2 and she refused to eat or drink, vet just gaave her something for the vomiting but did not think it was due to the trifexis. day 3 was great, her appetite was back and no vomiting. on day four now and she did not eat her second meal and vomited once. My poor dog, I feel like such a horrible mom. wish I could detox.

  31. Kathryn on 21 Jan 2013 at 10:47 pm #

    I have a 8 year old Bichon Poo. She was on Interceptor for heart-worm preventative. The main brands of flea treatments would say 3 months for flea preventative, then only last a month at best. Plus it didn’t help my neighbor refuses to treat his 2 Bull Mastiffs for parasites. I used Flea Busters and nothing helped. So anyways…Her vet started her on Trifexis and she has been doing fantastic. No vomiting, no change in her bouncy personality, and most importantly…no fleas!!! Everyone is entitled to their own opinion, but calling it “poison” may be a little harsh. To say “it just wasn’t for my dog would suffice”. As with humans, some meds make some people sick, but work magic with others. These kind of choices really should be discussed and made between the dog owner and vet. As with all meds, there are always risks involved. But I also hate to see people potentially scared off by someone else’s bad experience. If your vet doesn’t have the time to answer all the questions you may have about this or any other meds you may have…perhaps its time for a new vet.

  32. Lori on 22 Jan 2013 at 9:12 pm #

    Guys, those of you who are talking about Interceptor and COmfortis, Don’t you realize that is what Trifexis is? IT is those 2 pills combined. That is why my vet told me to buy it. I use Interceptor and it is on backorder and I have used Comfortis for 2 years. My Comfortis pill was already costing the same as the Trifexis pill. It is the Comfortis part of Trifexis which causes problems, Comfortis has to be given with a full meal of canned dog food. It says it on the packaging and it must be canned. Otherwise you can have vomitting. My shih tzu, and brussels and yorkie have had no problems with Comfortis, which is all Trifexis is, with their Interceptor added in.

  33. Joshua on 31 Jan 2013 at 10:24 pm #

    I gave Trifexis to my 3 poms who are 7, 11 and 21 pounds. On July 4th 2012 they where miserably infested with fleas. In a matter of hours I could physically see the fleas walking super slow and some were already dead! There were no adverse reactions in my dogs but my 11 pounder super smart guy kept spitting his pill out so I melted it in some water and force fed it to him in an eye dropper. Here we are 6 months later and the fleas have just now returned. I only gave them 1 dose. I could actually smell the chemical on my 7 pounder after 4 and a half months so I didn’t want to over treat them. I thought I could save a little by using Advantix II but nope, $48.00 dollars later there is absolutely no change in my dogs scratching. For me personally I love Trifexis and consider it a miracle pill. Im sorry for anyone who lost a pet over it or even one that got sick. Too bad there wasn’t a pre-screen test to see how are pet’s would react to the treatment.

  34. Mundina on 11 Feb 2013 at 12:04 pm #

    My 10-year-old Scotch terrier started on Trifexis in July 2012 (because of Sentinel being unavailable) and immediately developed a skin issue. I blamed Trifexis. I took him OFF and have used TriHeart Plus since then….BUT the skin issue remains. What he has are little “pimples” breaking out all over his back. They dry and crust over and then new ones “erupt”. If I don’t keep him bathed, then secondary fungal infection sets in. I THINK the problem is the “insecticides” in these pills (Trifexis is spinosad, TriHeart is pyrantel) (my old faithful Sentinel was lufenuron) I think this is giving him a skin rash. He doesn’t itch. The “pimples” bother ME more than they do HIM. His hair is NOT falling out. I have to keep his back hair cut really short…instead of his nice Scottie length. :(
    My vets don’t really concur on what the problem is.
    Anyone else with this skin issue?

  35. Marlene on 14 Feb 2013 at 1:58 am #

    For the folks that are happy with Trifexis, what are you using for Ticks?
    Thanks for all of the above comments.

  36. Nicole on 15 Feb 2013 at 12:20 pm #

    Trifexis kills ticks also.

  37. Carolyn on 27 Feb 2013 at 12:49 am #

    I have been taking my dog to Auburn for chemo and while there I met a couple whose beautiful lab nearly died from her reaction to Trifexis. My dogs hate the pills so much they won’t even take them wrapped in ground beef and the smell makes me gag. I really miss Sentinel!

  38. Lynn on 23 Mar 2013 at 8:51 pm #

    OMG… These aren’t reviews, these are horror stories! I’ve never used the Sentinel b/c I want something that kills the adult flea as well so my dogs (Amer. Bulldog/Border Collie mix and a Dashchund/Black Lab mix) have never had any problems! I lived in FL and now Ga, so didn’t want to worry about a flea infestation in one place and ticks in another. I’ve tried the Comfortis and Revolution and it just doesn’t work as well for me. The Revolution for cats however, works magically! Prior to getting cats I used Advantix, and as for killing the fleas it did its job. I love Trifexis and the fact that one dose handles everything except a good washing! I either give it to my dogs in between giving treats or in a turkey dog b/c I found just shining it down their throats makes them a little sick. Other than that, its a miracle chewable. I hope everyone who has had trouble w/ any of these medications find something that their dogs can use b/c its here to help not harm. So sorry for so many losses.

  39. Grace on 01 Apr 2013 at 2:19 pm #

    @Nicole, please read the literature related to the medicine before you give advice to someone else. Trifexis DOES NOT prevent and/or treat ticks! It only kills biting adult fleas and the 3 kinds of worms (hookworm, roundworm, whipworm). People who live in areas of high tick population must use a supplemental medicine for tick prevention if your dog is only on Trifexis!!

  40. KTinATL on 02 Apr 2013 at 12:25 am #

    PV-We have been on Sentinel for years and we are in FL once a month. I have no problems with fleas here (Atlanta) but every time I bring her down there she ends up with fleas. We stay with my friend that has indoor cats, concrete flooring, and lives on the second floor of an apartment building. And she (and everyone else we know down there-pets or not) have huge issues with fleas. So the Sentinel alone does not work for the flea problem there. We also always take extra Capstars (impossible to find down there because they’re always sold out) and a topical flea treatment too. I think that’s entirely too much to be putting my dog through for one weekend a month. That said the Trifexis has a 100% flea kill rate. We are going to start trying it tomorrow and we will be back in FL (Gulf coast) to put it to the test in the next few weeks. I have heard that it causes seizures but no one on here seems to have had that concern…My vet is my breed specific (English Bulldog) and seems to be fine with it so we’ll see what happens.

  41. We crush trifexis with a small hammer & roll it in peanut butter for our 16 pound shih/apsos mix & sheba has no problem getting it down! haven't seen adult fleas but think i see flea dirt? Kathe Hunter, cottonwood, California on 22 Apr 2013 at 1:20 am #

    We crush trifexis with a little hammer & roll it in peanut butter! Our Little 16 pound Shih/Apsos mix has no problem getting it down! Haven’t seen adult fleas on her but “think” i see flea dirt? No itching or sickness from the trifexis either! This will be her 5 th month taking it as none of the topical stuff worked on her & we did have her on Heart Guard & switched her 5 months ago to trifexis! We are going to start giving her flea baths now that the weather has changed cause she loves going outside & laying in the dirt! Hope it works for what I think is flea dirt :/ K

  42. JT on 24 Apr 2013 at 10:42 pm #

    I have an 8 lb Havanese who is 15 months old. She has been taking Trifexis since she was 4 months old and has never had a reaction of any kind. I dose her by feeding breakfast first and then I put the Trifexis in a Greenie pill pocket, which she loves. She’s never vomited, been lethargic, had a seizure, or had skin or joint issues. When I’ve asked my vet about issues with Trifexis he says there isn’t verifiable data on it. It makes me wonder if people are taking their dogs to the vet when this happens and also reporting issues to the FDA, department of health or office of animal welfare. I suspect that the majority of dogs do fine on it but their owners don’t share their positive experiences on the Internet; instead, the ones who have problems do comment online, which skews the perception of risk.

  43. Burton Gotshall, on 27 Apr 2013 at 4:02 pm #

    I’ve read a lot of individual responses for both sides with NO Consensus of opinion.
    It all seems a bit moot since Sentinel has as yet no said when it will be able to provide their pills.
    I just used my last pill this month. so I have to do something soon.

  44. Bobbie on 05 May 2013 at 8:10 am #

    For those that want Sentinel ….. Sentinel is back ! Factory is up and running and Sentinel and Interceptor.

  45. Krysten on 05 May 2013 at 11:46 am #

    I was very skeptical of using Trifexis after reading all of the reviews, but I do believe every dog can react differently. I have recently used this pill on all 3 of my dogs-10 yr old Chihuahua (9 lbs), 5 yr old American Bulldog (71 lbs), and 2 yr old Pitbull (60 lbs). My Pitbull has a very sensitive stomach..it took me months to find an adult dog food that would not make him horribly sick at his stomach. All three of my dogs took this pill without any issues. They ate them right out of my hand..including my picky Chihuahua. I have not noticed any side affects or sickness, thank God, in any of my dogs. My vet did warn me to try the first pill and see how they reacted, because it could make them sick. I am so sorry for the people who have lost their pets or experienced horrible side affects =( For me, I like Trifexis and it was a good suit for my animals.

  46. Anita on 07 May 2013 at 5:52 pm #

    My 16 lb mixed breed threw up after taking it the first time and hates the taste of it! For several months he had no vomiting when he got it after a meal but he continued to hate the taste; I had to shove the pill down into his throat several months! Tonight I cut it in half and wrapped each half in peanut butter. He swallowed the first peanut butter ball but even when I crushed the second half of the pill and mixed it into peanut butter he refused to eat it! I think it stinks and can hardly believe any dog would swallow it like it was a treat! Is it dangerous? I don’t know… If there were a viable option I would try it. Bobbie on May 5th above states Sentinel is back – does anyone know if this is true? Any other options? This is my first dog and I do hate making him miserable. He is, of course, perfect :-)

  47. Sam on 16 May 2013 at 10:30 pm #

    When I got the Trifexis for my dog, they gave me a tick collar. It is called a scalibor collar. preventic collars will work, but I have never tried it. My dog has had the scalibor collar on for almost a week and I haven’t found any ticks on her so I guess it works! I just gave my dog her first dose of trifexis so we shall she how she tolerates it!

  48. Patti on 31 May 2013 at 10:31 am #

    My 10-mo-old Labradoodle has used Trifexis since he was 3 months old and never had any problems with it. I always give it with a meal though. He actually seems to like it and chews it all by itself. He thinks it’s a treat. Thus, I’m surprised about the stories that it’s bad tasting. Who knew? When I first got him he had 1 flea on him and 1 flea a couple weeks later that I noticed when bathing him. Since a couple weeks after starting the Trifexis I’ve never seen another flea. I live in Alabama. My vet (College of Veterinary Medicine in Auburn) assures me it’s safe.

  49. Jeff on 10 Jun 2013 at 5:17 pm #

    I gave my boxer/bulldog two doses of Trifexis and I will not be giving him another. First of all it was a chore to give it to him due to the chemical smell, even though I hid the pill in his wet food. After the first dose he threw up within four hours. After the second dose he lasted six hours before throwing up. He was lethargic and sick(vomiting) for several days after which was unusual for him.

  50. Karen on 24 Jun 2013 at 2:54 pm #

    My rescued babies (Mini Poodle and Shih Tzu) have been on Trifexis since I got them (2 years). Neither has had a problem with nausea, vomiting, lethargy,skin conditions, etc. And neither has ever had a flea, tick or worms. I am switching vets due to the 1 hour drive (even though I loved the vet). One vet I am considering uses Sentinel and one uses Trifexis. Both are excellent vets according to my doggie parent friends. Now that I have read these comments I am totally confused as to which might be best. My concern with Sentinel is that it does not kill adult fleas. Yet, Sentinel is less than half the cost of Trifexis. And Patti, you are lucky to have a vet at Auburn. Often extremely ill animals in Atlanta are sent to Auburn due to their high reputation for saving extremely ill fur babies. I do know I will NEVER use a topical flea killer as one I feel 100% certain killed my cat. Also if anyone has a super vet in the Grayson, Gwinnett County Area (Metro Atlanta), please facebook me a message. Thanks. Karen Meredith.

    to KTinATL I am interested to see how your baby does on Trifexus.

  51. Kat on 02 Jul 2013 at 9:09 pm #

    I’ve got a 4 month old miniature Australian shepherd and I’m trying to decide which medication to put her on. Her breeder specifically said never to give Aussies ivermectin as it can cause seizures and even death… Unfortunately, one of the pups in the litter was exposed to it and eventually passed away. I’m scared to give her anything based on all the horror stories here. After noticing a bunch of pimple like bites on her I finally washed her in a sentinel shampoo and applied sentry fiproguard. Any recommendations as to what I should do next? A vet recommended trifexis but I’m just not sure. I live in South Carolina and fleas are definitely an issue.

  52. Abby, PetMeds Pro on 05 Jul 2013 at 9:27 am #

    Hi Kat. Here’s an article about the MDR1 gene in dogs from the herding group that may be of help: http://blog.petmeds.com/pet-pharmacy/mdr1-a-generally-safe-drug-could-turn-deadly/
    ~ Abby, PetMeds Pro

  53. Mary on 09 Jul 2013 at 2:33 pm #

    I started giving my two corgis Triflexis in May, noticed my tri color was very lethargic after first time. Ask the vets office, she said divide and give two days in a row in food. Tri color still lethargic, so this month we are switching them to Sentinel. I have never had flea problem, so mainly concerned with the heartworm disease, which our vet said she is seeing a lot of now. Anxious to see how they do on Sentinel. Have not had them on heart worm medicine until this year.

  54. Courtney on 12 Jul 2013 at 1:25 pm #

    My puppy was on Trifexis for 4 Months before we figured out the adverse reaction she had to it. Everytime after we gave her the pill she just couldn’t hold her bladder and even odder was that she wouldn’t jump into the car or anything.

    Every month we gave it to her she would have bad diarrhea and would pee in the house. It was terrible because we would be going to take her out and she would pee while going outside. She just couldn’t hold it. She also seemed to get “infections” for a week every time after we gave it to her.

    A month later after being off of it we haven’t had any issues and she jumps into the car without a second thought. Which is nice because I was tired of lifting her into the car. I just really don’t recommend Trifexis. Is you notice anything different after giving it to them you should be really careful, because their body is telling you they can’t handle it; especially if they are vomiting on it.

  55. Mary on 23 Jul 2013 at 5:44 pm #

    I have given both my black toy poodles Triflexis for 2 yrs. I have had throw-up with meals or several hrs later. I now give it 3 hrs after a meal. At least if they throw-up then, I feel sure the pill has dissolved. A few months ago my black male has developed light patches. He is not of ‘parti’ bloodlines. He is also showing lots of wht. hairs and appears to be a charcoal color now, not solid black like his sister, who has had no hair color change. My question is, can Triflexis cause this change of hair color?

  56. Abby Rosenberg on 24 Jul 2013 at 1:27 pm #

    Mary, according to the manufacturer the following are potential side effects:

    “Like all medications, sometimes side effects may occur. In some cases, dogs vomited after receiving Trifexis. If vomiting occurs within an hour of administration, redose with another full dose. During field studies, no severe or prolonged vomiting occurred. Additional adverse reactions observed in the clinical studies were itching, decreased activity, diarrhea, inflammation of the skin, redness of the skin, decreased appetite and redness of the ear. All reactions were regarded as mild. For technical assistance or to report a suspected adverse drug reaction, contact Elanco Animal Health at 1-888-545-5973. ”

    ~ Abby, PetMeds Pro

  57. jacki on 30 Jul 2013 at 3:14 pm #

    I have had my current Rotties on trifexis since they were young and my Rotties prior since Trifexis first came out. I love it.. No fleas. which is hard to say when living in Florida. jIust put a little cheese on it and they swallow it down. I agree with others that as with all meds, each person/dog is different. I love trifexis and will continue using it.

  58. Nick on 31 Jul 2013 at 1:05 am #

    Fact of the matter is, dogs are like people, every dog will react differently to the medication. Some dogs may have minor side effects, some may have severe and some none at all. I give trifexis to my 2 year old beagle and she is fine every time. No vomiting, no loss of energy, loss of appetite etc. so everyone who is worried about giving they’re dog one or the other of these two meds, you’ll either have to just try it on your dog or go without. The only way to know is to try and remember some dogs are more sensitive to medications than others. But in my case I love trifexis for my dog, it works great. She has even been around and played with another dog who had fleas and never even scratched herself once or got any parasites. I give it 5 out of 5.

  59. Sandy on 12 Aug 2013 at 6:27 pm #

    I have been researching trifexis because my Rosie (mix) has started having trouble not being able to hold her bladder. Never had this problem until we gave her trifexis. She also vomited a couple hours after her dose. She laid around fro 2 or 3 days and I thought she might be pouting because of her vet visit. She had to be trimmed and anytime she has to leave the house it seems to traumatize her. But now after reading these posts I think it was the medicine. She will not get another dose of Trifexis!

  60. James on 14 Aug 2013 at 5:15 pm #

    I have used trifexis for 2 years and it works great on my goldens. It is the first medicine I have ever used that has prevented them from getting any fleas. It’s the best.

  61. Jaclyn on 24 Aug 2013 at 4:31 am #

    Anyone ever have limping problems as a side effect of Trifexis? Our rottweiler/pit mix has been on Trifexis since she was 4 months (she will be 2 in november). The only side effect she’s ever had is a little more tired than normal. Well last night we got home from our neighbors (we were gone not even an hour) and she greets us at the door with her back right leg hoisted in the air. She wouldn’t put it down or put any pressure on it for 20 or so minutes. The only thing out of the ordinary that she did today was take her Trifexis for dinner. NO idea if this has anything to do with limping. I have been up every hour tonight checking on her laying in her bed next to my husband. She seems fine now. I used to swear by Trifexis but if this horrible, painful limping is a side effect of it I don’t want anything to do with it anymore!

  62. Lauren on 08 Sep 2013 at 10:37 pm #

    I had my puppy 16 week shep mix on sentinel and it did nothing for her! Sentinel does NOT kill adult fleas! Nor is it a preventative for adult fleas. My vet recommended Trifexis and so far it has worked great! It was a little bit of a struggle to get her to swallow it (just put it in peanut butter) Obviously no medicine is going to taste great. My entire family has all their dogs on trifexis now :)

  63. Sean McKillop on 09 Sep 2013 at 11:00 am #

    I am looking at switching to one of these products. I have a 7 yr old Min Pin who has been having flea issues lately. I dip, spray and bath only to have fleas again in a few days. We have been having an extremely wet summer and I think the conditions are perfect for flea breeding. Any input would be helpful as I wish to make an informed decision and do not want to jeopardize my dogs health.
    Thanks

  64. Jackie on 09 Sep 2013 at 12:03 pm #

    I have an English Mastiff and a miniature schnauzer and they are both of Trifexis and I have NEVER had an issue. I entertained the idea of looking for something a bit cheaper but money really shouldnt be an object when caring for my babies so I am sticking with it. I have been using Trifexis about since it came out and its amazing and no problems nor have I ever heard of any problems with it so I will stick with it.

  65. Maritza on 10 Sep 2013 at 7:59 pm #

    I just purchased Sentinel for my dogs – switch from topical for fleas & ticks & Heartgard. What has been the overall experience in reference to switching? I’m truly concerned about any flea problems as I haven’t had any with the change.

  66. DJ, Soco and Bentley's Dad on 21 Sep 2013 at 6:54 pm #

    We have had our babies on trifexis since birth.. Soco has been on it for 4 years and Mr. Bentley has been on it about 6 months now.. They have had no problems except neither like the taste.. I break them in to about 5-6 pieces and feed it to them in some cheese and they’ll eat it right up.. No vomiting and they seem to feel totally fine/normal after dosing.. I came online to search to see if PetSmart had it and came across some pretty scary S&#$ about it, but that’s usually easy on the internet.. It’s only good to scare you.. I think you can find something saying it’ll kill you regarding just about everything on the internet.. I took a new med once and went into anaphylaxic shock and couldn’t breathe and had crazy muscle spasms, so that kind of thing can happen to ANYONE.. But I called 911 and got fixed up and was fine.. Just ALWAYS keep a constant eye on your pet for the first few DAYS (Yes, DAYS) after giving your beloved pet new meds because they can’t always come tell you they need “911″

  67. MomaJo on 25 Sep 2013 at 4:32 pm #

    The Trifexis pills have a very unpleasant smell and I assume taste. My 98lb Lab, Wilson, would spit the pill out of anything I tried to hide it in. Several months ago I had an idea to try and cover up the smell of the pill so I crushed it up in a can of sardines. Wilson ate it all up with no issues. He has had no adverse issues taking Trifexis.

  68. GoldenMom on 08 Oct 2013 at 9:53 am #

    I used Sentinel for 2 dogs successfully for many years. Treated them with Capstar after boarding just in case. When Sentinel became unavailable, we switched to Trifexis. Suddenly my Golden began having ear infections. Now she has horrbile skin issues (the other had passed after 14 years). We’re going back to Sentinel, now that it’s back. Hopefully, the anti-fungals, probiotics and vitamins will get our beautiful, wonderful, fur baby back to full health. I swear by Sentinel – never saw a single flea in all those years we used it, and it was safe for my now-deceased herding dog who could have had issues with other products.

    P.S. – My dog also spit out the Trifexis repeatedly. Maybe these pups know something we don’t.

  69. Bill Harger on 10 Oct 2013 at 9:00 pm #

    I am a breaded of the most awesome dog in the world, the Australian Shepherd.
    My Aussies have all been on Sentinel since they were 4 weeks old. In 12 years, I have never SEEN A FLEA, never had to have one treated for worms, never had a dog require treatment of Heart Worms.
    I keep a supply of it on hand and you couldn’t pay me to switch to trifexin or anything else. It ain’t broke, so why should I fix it?
    Bill

  70. kerry on 12 Nov 2013 at 6:40 am #

    Recently after taking trifexis for a year our Snoozy (terrier mix) became ill 7 days after pill started licking carpet etc eating some grass-symptoms abated then within more days became worse. brought her to vet who gave her valium to no avail-vet thought she was stressed. ? no stress that i know of) that night up all night while she incessantly licked carpet everything and all she would do outside was eat grass-back to vet after she started vomiting. Brought her back to vet who did a barium sturdy with ex-rays no obstruction gave her cerenia by injection. Brought her to emergency medical hospital after she developed bloody stools from diarrhea and she became lethargic. After 24 hrs IV fluids, antibiotic, antifungal med she improved. Brought her home and saw the info about trifexis on t.v. I will call vet today and request another med.

  71. Mike on 16 Nov 2013 at 5:15 pm #

    My shih-tzu and Maltese-shih-tzu both have taken a year of trifexis with no problems whatsoever. They don’t consider it a treat, though, and take it with peanut butter or cheese.

  72. Gary Eaker on 19 Dec 2013 at 2:37 pm #

    I have a 4.5 year old AmStaff that came to my family 6mnths ago in FL from SC. Tank was 70lbs of pure muscle that loved to run and leap like a deer. When started on Trifexis 6 mnths ago he seemed to tolerate it just fine. After 4 mnths of Trifexis he tore his cranial cruciate ligament in his right leg. Then 2 weeks later he did the same to his left rear leg. I don’t know if Trifexis had anything to do with this or not but the scary stories about dogs suffering and dying are terrible. Wouldn’t it make sense to make a first dose of Trifexis about a tenth of the normal dose as a tolerance test? Then if a dog has any adverse reactions perhaps they won’t get seriously sick or die?

  73. Jean Malmgren on 21 Jan 2014 at 4:20 pm #

    We have been battling our adult Pug’s skin problems for 18 months now. She itches constantly and crawls on her belly to itch to point of bleeding. Terribly frustrating. We have eliminated everything from her diet except Superior limited ingredient dog food, and only treats of cooked turkey. After a round of steroids and a vow of NO extra food sources she was doing really well until suddenly, itching and scratching again. Another round of steroids, doing well, then AGAIN suddenly, itching and scratching. Today it dawned on me……she was flaring up each time I gave her the Trifexis that we put her on 18 months ago. Damn I wish this stuff would have a disclaimer on it to watch out for skin problems. Will definitely avoid this stuff in the future.

  74. GMV on 14 Feb 2014 at 5:42 pm #

    Trifexis Users Take Note: We have a hound/lab that was a rescue dog. We got him when he was a year and half old. Very healthy dog. He just turned five years old. All shots, regular check-ups with absolutely no issues. Switched him to Trifexis when Sentinel went off the market. He has been on Trifexis for over a year. I never associated any side effects to the medication but he was known to have spells of eating grass, being a little lethargic at times but he always perked up after a few days. Again, I never was looking to find that his monthly medication (Trifexis) was a problem. I do know that he did not like taking it and I told the vet recently that he does not like taking it even though he loves any kind of treat. So, he has been on Trifexis for over a year. On January 17, I give him his monthly dosage. My husband notices that his head is really warm and that he must be running a fever. I made a mental note that he had just taken Trifexis two days earlier. He seemed lethargic and I commented to my daughter I thought Buddy had cabin fever. We all tend to get this in the winter. Another week or so goes by and on Sunday, Feb 2nd, he was laying in his bed and all of sudden started jumping up trying to get his feet under him and he could not stand. His legs were out to the sides. He had no muscle control, he was drooling profusely and shaking. His eyes were rolling round in his head and he had the look of terror on his face. I got him over to the tile floor because he was drooling so bad and thought the cooler floor would be good for him. I got the hospital on the phone and talked to them. They said it sounded like he broke a fever and had a seizure. Being familiar with children/adult seizures, it was exactly what I said that it was like he had a seizure. Within a few minutes he was recovering. His heart was beating more normally and he was able to stand up after about 10 minutes. What a scare! I took him to the vet the next day. I asked her if it could be the heartworm medication because of the things I identified above (fever, lethargic, etc) She said there is no medical evidence that Trifexis causes seizures and that bigger dogs especially retrievers are more susceptable to seizures but not associated with the drug. Though she did not think it was Trifexis she said we could switch him back to Sentinel. I said that we would do that and I would bring the remaining pills back for refund. She agreed. Later that day, I got on the internet and found all these people who had lost their dogs possibly due to Trifexis. Though I called the vet and told her, she still held her ground that there was no medical evidence. I re-minded her to keep checking those medical journals for their findings but in the meantime my dog was not going to be taking Trifexis for sure. Buddy’s seizure was 16 days after he took the pill and this is very consistent with what some of the people say that it is about 2 – 3 weeks after the med is taken. So, all of you that have been using this med without any problem…be ware. It may build up in their system or react after a delayed period of time as far as I am concerned. I also think I ignored some signs along the way that I should have documented. He is a very healthy dog and I hope that he does not have another seizure as it was an awful experience for all of us.

  75. Matt on 03 Mar 2014 at 6:22 am #

    Just used Trifexsis to treat my 200 gallon reef tank today. Used the whole pill against acropora eating red bugs. Seemes to have worked at killing the bugs. After 12 hours I returned my carbon to the reactor and turned my skimmer back on. The overall result. Dont see red bugs. Some corals are not very happy, others seem OK. Off to do a water change today. My protein skimmer is pulling a lot out of the water.

  76. Alex on 20 Mar 2014 at 6:23 pm #

    I wanted to comment that my dog has been pretty much fine so far on this med. I wonder if these 700 people know that Heartguard has killed more herding breeds than trifexis has killed any dogs. 700 cases since it was introduced, I’ve read more and seen more scientific papers on how many dogs have seizures and die from heartguard and Iverheart.

    I may be wrong about trifexis and my dog may one day have a reaction but so far its the lesser of two evils.

  77. Wayne on 25 Mar 2014 at 9:34 pm #

    Our Australian Cattle Dog, currently nine months old, has been on Trifexis since she was 12 weeks old. She has never vomited after taking it, she is never lethargic, and actually takes hers like its a treat. We have had no problems with here loosing hair, itching or any other side effect as far as we can tell. As with any medication, I am actually more worried about long term effects, but it is only a concern and I haven’t seen anything saying that there could be long term effect. We also use Trifexis on our 12 year old rat terrier and my in laws use it on their dachshund terrier mix, none of the dogs have experience any side effect, but they do not like taking it. We are very happy with this product.

  78. Mark on 03 Apr 2014 at 6:07 pm #

    I have a 3 year old, female, German Shepherd / Retriever Mix who has been on Trifexis for almost a year without any problems; and she hasn’t had any Flea or Worm issues, either. I would recommend Trifexis, but like all medicines, especially the ones that kill a parasite, I would discuss it with your Vet and monitor your Pet. If your Pet has issues with other medications or foods, then I would consider all of your options. Personally, I think Trifexis is a great product.

  79. Bobby on 15 May 2014 at 6:20 pm #

    Trifexis works. I’ve been using it almost a year. I’ve never tried the cheaper Sentinel. I want to try it because it’s cheaper, but it says that it doesn’t kill adult fleas. I don’t see the point in using it. I have two dogs on Trifexis. One one year old female Rat Terrier and one three year old male Chi/Dach. I love my dogs. I hate fleas.

  80. Ashley on 25 Jun 2014 at 11:21 am #

    I switched my 2 dogs, a 3 yo Shar Pei/Rottie and a 1 yo Rat Terrier, to Sentinel two months ago and it sucks! They’ve always been on Trifexis and have never had any problems. No vomiting, never lethargic and never any fleas!! We tried the Sentinel out because it is cheaper but now my 3 yo has terrible flea dermatitis so we will be going back to Trifexis next month. I believe dogs react differently to medications just like us humans. I’m sorry to everybody who has lost their dog after taking ANY medication :(

  81. brigitte on 14 Jul 2014 at 2:57 pm #

    To the person asking about revolution. I had all my dogs on Revolution and never had any problem with heartworm or fleas or anything else, but you have to be consistant and make sure until it dries they don’t rub it off.

  82. frank on 17 Jul 2014 at 2:49 pm #

    I treated my 2 Golden Retrievers with Sentinel for years without any problems. The flea control was excellent and I liked knowing we were preventing worm & parasite infections. These dogs both have passed on now. I never realized there were so many adverse reactions associated with this drug. I am currently shopping around for the least invasive, safest flea treatment for my new dog, an Akbash rescue who has a reported flea allergy.
    My neighbors treated their beautiful Goldendoodle with Trifexis for over a year before they realized it was causing major health problems. He was sick, lethargic, lost all his hair, and had terrible skin reactions. Their Vet did not associate his illness with the flea medication until after they had spent thousands of dollars on unnecessary medications and testing. He was fine after they discontinued the Trifexis.
    After reading all of these horror stories I am hesitant to use any oral or topical flea pesticides on my pets, but if I really need to treat them, I would start with one dose and monitor them carefully for side effects.

  83. Kristopher on 03 Aug 2014 at 5:42 pm #

    Speaking from experience, I’ve had 1 Corgi Mix on Trifexis for some time now and had 2 poms on it for quite a while too.. none have showed any adverse reactions to it at all.. now i won’t say that some dogs don’t have adverse reactions to it but, I won’t believe some hype that people are trying to spout without proper research being done.. for all that is known, they could’ve had some sort of other problems or even infested with heartworms when they took their first dose.. supposedly (i’ve heard) if they have heartworms ahead of time, then it could cause problems.. which is why any responsible vet will run tests on your pets before assigning medicine all willy-nilly.. heck we had to have multiple tests run for heartworms before our vet would even give it to our dog.. but as others said, just like people, animals can have adverse reactions that won’t be present in every dog..

  84. martha on 22 Aug 2014 at 6:45 am #

    my yorkie throws up every month (after about 8 hours yellow bial) and gets lethargic …but my vet says he has to take it… and my chi.pom runs when he hears me opening the trifectis and sleeps all day after dosage (unusual for him)… and my chi.minpin gobbles it up without any force but throws up sometimes.
    .
    …something inside me tells me this can’t be good…. but my vet insists it’s safe.

    i wish there is another solution.

    i will try cutting these in half and giving 1/2 morning 1/2 evening with food and pray they dont throw up twice…

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